Limited DNase I nicking as a probe of gene conformation.
We have extended the use of pancreatic DNase I as a probe of chromatin structure by exploring the accessibility of an active gene to the introduction of the first single-stranded nick. We show by a target analysis that the beta-globin gene is about 25-fold more sensitive to single-site nicking than...
Guardado en:
| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1980
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348618/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6929527/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.4.1907 |
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