Replication Fork Collapse and Genome Instability in a Deoxycytidylate Deaminase Mutant

Ribonucleotide reductase (RNR) and deoxycytidylate deaminase (dCMP deaminase) are pivotal allosteric enzymes required to maintain adequate pools of deoxyribonucleoside triphosphates (dNTPs) for DNA synthesis and repair. Whereas RNR inhibition slows DNA replication and activates checkpoint responses,...

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Main Authors: Sánchez, Arancha, Sharma, Sushma, Rozenzhak, Sophie, Roguev, Assen, Krogan, Nevan J., Chabes, Andrei, Russell, Paul
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486156/
https://ncbi.nlm.nih.gov/pubmed/22927644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01062-12
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