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Detection of Botulinum Neurotoxin Serotype A, B, and F Proteolytic Activity in Complex Matrices with Picomolar to Femtomolar Sensitivity

Rapid, high-throughput assays that detect and quantify botulinum neurotoxin (BoNT) activity in diverse matrices are required for environmental, clinical, pharmaceutical, and food testing. The current standard, the mouse bioassay, is sensitive but is low in throughput and precision. In this study, we...

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Detalhes bibliográficos
Main Authors: Dunning, F. Mark, Ruge, Daniel R., Piazza, Timothy M., Stanker, Larry H., Zeytin, Füsûn N., Tucker, Ward C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485704/
https://ncbi.nlm.nih.gov/pubmed/22923410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01664-12
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