Binding of sea anemone toxin to receptor sites associated with gating system of sodium channel in synaptic nerve endings in vitro.

Iodination of toxin II from the sea anemone Anemonia sulcata gives a labeled monoiododerivative that retains 80% of the original neurotoxicity. This derivative binds specifically to rat brain synaptosomes at 20 degrees C and pH 7.4 with a second-order rate constant of association ka = 4.6 x 10(4) M-...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Vincent, J P, Balerna, M, Barhanin, J, Fosset, M, Lazdunski, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1980
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348554/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6103536/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.3.1646
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