Binding of sea anemone toxin to receptor sites associated with gating system of sodium channel in synaptic nerve endings in vitro.

Iodination of toxin II from the sea anemone Anemonia sulcata gives a labeled monoiododerivative that retains 80% of the original neurotoxicity. This derivative binds specifically to rat brain synaptosomes at 20 degrees C and pH 7.4 with a second-order rate constant of association ka = 4.6 x 10(4) M-...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Vincent, J P, Balerna, M, Barhanin, J, Fosset, M, Lazdunski, M
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1980
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348554/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6103536/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.3.1646
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