HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells

BACKGROUND: Lens epithelium–derived growth factor (LEDGF/p75) is a cellular co-factor of HIV-1 integrase (IN) that tethers the viral pre-integration complex to the host cell chromatin and determines the genome wide integration site distribution pattern of HIV-1. Recently, we demonstrated that HIV-1...

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Main Authors: Schrijvers, Rik, Vets, Sofie, De Rijck, Jan, Malani, Nirav, Bushman, Frederic D, Debyser, Zeger, Gijsbers, Rik
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
Assuntos:
Short Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485173/
https://ncbi.nlm.nih.gov/pubmed/23046603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-84
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