Mitochondria and sarcoplasmic reticulum as model targets for neurotoxic and myotoxic phospholipases A(2)
Certain neurotoxins and myotoxins from snake venoms have phospholipase A(2) activity (phosphatide 2-acylhydrolase, EC 3.1.1.4), which appears to be necessary for their toxicity. Several of these toxins inhibit the net uptake of Ca(2+) into sarcoplasmic reticulum vesicles and brain mitochondria. We h...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1980
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348491/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6929489/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.3.1346 |
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