Dose-Response Relationship Between Tissue Concentrations of UC781 and Explant Infectibility with HIV Type 1 in the RMP-01 Rectal Safety Study

A retrospective correlational analysis of UC781 (0.1, 0.25%) gel pharmacokinetics (PK) and pharmacodynamics (PD) was undertaken using data generated in the RMP-01/MTN-006 Phase 1 rectal safety study of the UC781 microbicide gel, where strong UC781-related inhibition of ex vivo biopsy infectibility (...

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Bibliographic Details
Main Authors: Richardson-Harman, Nicola, Mauck, Christine, McGowan, Ian, Anton, Peter
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2012
Subjects:
Clinical Trials/Clinical Studies
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484735/
https://ncbi.nlm.nih.gov/pubmed/22900504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2012.0073
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