Enhancement of the dissolution rate and bioavailability of fenofibrate by a melt-adsorption method using supercritical carbon dioxide

BACKGROUND: The aim of this study was to enhance the bioavailability of fenofibrate, a poorly water-soluble drug, using a melt-adsorption method with supercritical CO(2). METHODS: Fenofibrate was loaded onto Neusilin(®) UFL2 at different weight ratios of fenofibrate to Neusilin UFL2 by melt-adsorpti...

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Main Authors: Cha, Kwang-Ho, Cho, Kyung-Jin, Kim, Min-Soo, Kim, Jeong-Soo, Park, Hee Jun, Park, Junsung, Cho, Wonkyung, Park, Jeong-Sook, Hwang, Sung-Joo
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2012
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484728/
https://ncbi.nlm.nih.gov/pubmed/23118538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S36939
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