Loading...

Chemical mechanisms for cytochrome P-450 hydroxylation: evidence for acylation of heme-bound dioxygen.

Using isotopic tracer methods, we have shown that dihydrolipoic acid (2,3-thioctic acid) acylates the distal oxygen of ferrous oxygenated Pseudomonas cytochrome P-450, forming a transient acyl peroxide intermediate that facilitates oxygen-oxygen bond cleavage. Single-turnover studies with 18O2 indic...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Sligar, S G, Kennedy, K A, Pearson, D C
Format: Artigo
Sprog:Inglês
Udgivet: 1980
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC348467/
https://ncbi.nlm.nih.gov/pubmed/6929480
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!