Single-dose safety and pharmacokinetic evaluation of fluorocoxib A: pilot study of novel cyclooxygenase-2-targeted optical imaging agent in a canine model

We evaluated preclinical single-dose safety, pharmacokinetic properties, and specific uptake of the new optical imaging agent fluorocoxib A in dogs. Fluorocoxib A, [Formula: see text]-[(5-carboxy-X-rhodaminyl)but-4-yl]-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamide, selectively bi...

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Detalhes bibliográficos
Main Authors: Cekanova, Maria, Uddin, Md. Jashim, Legendre, Alfred M., Galyon, Gina, Bartges, Joseph W., Callens, Amanda, Martin-Jimenez, Tomas, Marnett, Lawrence J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society of Photo-Optical Instrumentation Engineers 2012
Assuntos:
Research Papers: Imaging
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484194/
https://ncbi.nlm.nih.gov/pubmed/23117797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1117/1.JBO.17.11.116002
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