Loss of muscleblind-like 1 promotes invasive mesenchyme formation in endocardial cushions by stimulating autocrine TGFβ3

BACKGROUND: Valvulogenesis and septation in the developing heart depend on the formation and remodeling of endocardial cushions in the atrioventricular canal (AVC) and outflow tract (OFT). These cushions are invaded by a subpopulation of endocardial cells that undergo an epithelial-mesenchymal trans...

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Autores principales: LeMasters, Kathryn E, Blech-Hermoni, Yotam, Stillwagon, Samantha J, Vajda, Natalie A, Ladd, Andrea N
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484067/
https://ncbi.nlm.nih.gov/pubmed/22866814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-12-22
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