Inhibition of NF-κB Activation by 4-Hydroxynonenal Contributes to Liver Injury in a Mouse Model of Alcoholic Liver Disease

Long-term alcohol exposure sensitizes hepatocytes to tumor necrosis factor-α (TNF) cytotoxicity. 4-Hydroxynonenal (4-HNE) is one of the most abundant and reactive lipid peroxides. Increased hepatic 4-HNE contents present in both human alcoholics and alcohol-fed animals. In the present study, we inve...

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Detalhes bibliográficos
Main Authors: Dou, Xiaobing, Li, Songtao, Wang, Zhigang, Gu, Dongfang, Shen, Chen, Yao, Tong, Song, Zhenyuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2012
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483809/
https://ncbi.nlm.nih.gov/pubmed/22982442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.08.004
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