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A genetically encoded metabolite sensor for malonyl-CoA

Malonyl-CoA is the rate determining metabolite for long chain de novo fatty acid synthesis and allosterically inhibits the rate-setting step in long chain fatty acid β-oxidation. We have developed a cell-based genetically encoded biosensor based on the malonyl-CoA responsive Bacillus subtilis transc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ellis, Jessica M., Wolfgang, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483566/
https://ncbi.nlm.nih.gov/pubmed/23102226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.08.018
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