Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene

BACKGROUND: P-glycoprotein is a blood–brain barrier efflux transporter involved in the clearance of amyloid-beta from the brain and, as such, might be involved in the pathogenesis of Alzheimer's disease. P-glycoprotein is encoded by the highly polymorphic ABCB1 gene. Single-nucleotide polymorph...

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Bibliographische Detailangaben
Hauptverfasser: van Assema, Daniëlle ME, Lubberink, Mark, Rizzu, Patrizia, van Swieten, John C, Schuit, Robert C, Eriksson, Jonas, Scheltens, Philip, Koepp, Matthias, Lammertsma, Adriaan A, van Berckel, Bart NM
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer 2012
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483228/
https://ncbi.nlm.nih.gov/pubmed/23067778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2191-219X-2-57
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