Structures and Mechanisms of Antitumor Agents - Xestoquinones Uncouple Cellular Respiration and Disrupt HIF Signaling in Human Breast Tumor Cells

The organic extract of a marine sponge Petrosia alfiani selectively inhibited iron chelator-induced hypoxia-inducible factor-1 (HIF-1) activation in a human breast tumor T47D cell-based reporter assay. Bioassay-guided fractionation yielded seven xestoquinones (1 – 7) including three new compounds 14...

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Bibliographic Details
Main Authors: Du, Lin, Mahdi, Fakhri, Datta, Sandipan, Jekabsons, Mika B., Zhou, Yu-Dong, Nagle, Dale G.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482980/
https://ncbi.nlm.nih.gov/pubmed/22938093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np3002892
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