Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia

Stroma induces treatment resistance in chronic lymphocytic leukemia (CLL), possibly because of alterations in the BCL-2 family of proteins, which are key regulators of apoptosis. We previously developed BH3 profiling, a functional assay that assesses mitochondrial depolarization in response to BH3-o...

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Autors principals: Davids, Matthew S., Deng, Jing, Wiestner, Adrian, Lannutti, Brian J., Wang, Lili, Wu, Catherine J., Wilson, Wyndham H., Brown, Jennifer R., Letai, Anthony
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482860/
https://ncbi.nlm.nih.gov/pubmed/22955911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-414060
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