CpG Island Methylator Phenotype Positive Tumors in the Absence of MLH1 Methylation Constitute a Distinct Subset of Duodenal Adenocarcinomas and Are Associated with Poor Prognosis

PURPOSE: Little information is available on genetic and epigenetic changes in duodenal adenocarcinomas. The purpose was to identify possible subsets of duodenal adenocarcinomas based on microsatellite instability (MSI), DNA methylation, mutations in the KRAS and BRAF genes, clinicopathologic feature...

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Main Authors: Fu, Tao, Pappou, Emmanouil P., Guzzetta, Angela A., Jeschke, Jana, Kwak, Ruby, Dave, Pujan, Hooker, Craig M., Morgan, Richard, Baylin, Stephen B., Iacobuzio-Donahue, Christine A., Wolfgang, Christopher L., Ahuja, Nita
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482463/
https://ncbi.nlm.nih.gov/pubmed/22825585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0707
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