Novel Epitopes Identified by Anti-PrP Monoclonal Antibodies Produced Following Immunization of Prnp(0/0) Balb/cJ Mice with Purified Scrapie Prions

Prions, or infectious proteins, cause a class of uniformly fatal neurodegenerative diseases. Prions are composed solely of an aberrantly folded isoform (PrP(Sc)) of a normal cellular protein (PrP(C)). Shared sequence identity of PrP(Sc) with PrP(C) has limited the detection sensitivity of immunochem...

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Detalhes bibliográficos
Main Authors: Stanker, Larry H., Scotcher, Miles C., Lin, Alice, McGarvey, Jeffery, Prusiner, Stanley B., Hnasko, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482378/
https://ncbi.nlm.nih.gov/pubmed/23098297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hyb.2012.0022
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