Dysregulation of kappa-opioid receptor systems by chronic nicotine modulate the nicotine withdrawal syndrome in an age-dependent manner

RATIONALE: The mechanisms that mediate age differences during nicotine withdrawal are unclear. OBJECTIVE: This study compared kappa opioid receptor (KOR) activation in naïve and nicotine-treated adolescent and adult rats using behavioral and neurochemical approaches to study withdrawal. METHODS: The...

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Hauptverfasser: Tejeda, Hugo A., Natividad, Luis A., Orfila, James E., Torres, Oscar V., O’Dell, Laura E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482308/
https://ncbi.nlm.nih.gov/pubmed/22659976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-012-2752-7
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