Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging

Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Recent efforts in protein engineering have significantly increased the performance of GECIs. The state-of-the art single-wavelength GECI, GCaMP3, has been deployed in a number of model organisms and can relia...

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Hauptverfasser: Akerboom, Jasper, Chen, Tsai-Wen, Wardill, Trevor J., Tian, Lin, Marvin, Jonathan S., Mutlu, Sevinç, Calderón, Nicole Carreras, Esposti, Federico, Borghuis, Bart G., Sun, Xiaonan Richard, Gordus, Andrew, Orger, Michael B., Portugues, Ruben, Engert, Florian, Macklin, John J., Filosa, Alessandro, Aggarwal, Aman, Kerr, Rex A., Takagi, Ryousuke, Kracun, Sebastian, Shigetomi, Eiji, Khakh, Baljit S., Baier, Herwig, Lagnado, Leon, Wang, Samuel S.-H., Bargmann, Cornelia I., Kimmel, Bruce E., Jayaraman, Vivek, Svoboda, Karel, Kim, Douglas S., Schreiter, Eric R., Looger, Loren L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2012
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482105/
https://ncbi.nlm.nih.gov/pubmed/23035093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2601-12.2012
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