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Optimizing the GATA-3 position weight matrix to improve the identification of novel binding sites

BACKGROUND: The identifying of binding sites for transcription factors is a key component of gene regulatory network analysis. This is often done using position-weight matrices (PWMs). Because of the importance of in silico mapping of tentative binding sites, we previously developed an approach for...

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Main Authors: Nandi, Soumyadeep, Ioshikhes, Ilya
格式: Artigo
語言:Inglês
出版: BioMed Central 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481455/
https://ncbi.nlm.nih.gov/pubmed/22913572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-416
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