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Computational technique for improvement of the position-weight matrices for the DNA/protein binding sites
Position-weight matrices (PWMs) are broadly used to locate transcription factor binding sites in DNA sequences. The majority of existing PWMs provide a low level of both sensitivity and specificity. We present a new computational algorithm, a modification of the Staden–Bucher approach, that improves...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1084321/ https://ncbi.nlm.nih.gov/pubmed/15849315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki519 |
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