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Computational technique for improvement of the position-weight matrices for the DNA/protein binding sites

Position-weight matrices (PWMs) are broadly used to locate transcription factor binding sites in DNA sequences. The majority of existing PWMs provide a low level of both sensitivity and specificity. We present a new computational algorithm, a modification of the Staden–Bucher approach, that improves...

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Autori principali: Gershenzon, Naum I., Stormo, Gary D., Ioshikhes, Ilya P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084321/
https://ncbi.nlm.nih.gov/pubmed/15849315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki519
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