Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation

BACKGROUND: 2,4-Dimethoxyphenyl-E-4-arylidene-3-isochromanone (IK11) was previously described to induce apoptotic death of A431 tumor cells. In this report, we investigated the molecular action of IK11 in the HepG2 human hepatocellular carcinoma cell line to increase our knowledge of the role of pol...

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Detalhes bibliográficos
Main Authors: Radnai, Balazs, Antus, Csenge, Racz, Boglarka, Engelmann, Peter, Priber, Janos Krisztian, Tucsek, Zsuzsanna, Veres, Balazs, Turi, Zsuzsanna, Lorand, Tamas, Sumegi, Balazs, Gallyas, Ferenc
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481453/
https://ncbi.nlm.nih.gov/pubmed/22583868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-34
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