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Acid-sensitive TWIK and TASK Two-pore Domain Potassium Channels Change Ion Selectivity and Become Permeable to Sodium in Extracellular Acidification
Two-pore domain K(+) channels (K2P) mediate background K(+) conductance and play a key role in a variety of cellular functions. Among the 15 mammalian K2P isoforms, TWIK-1, TASK-1, and TASK-3 K(+) channels are sensitive to extracellular acidification. Lowered or acidic extracellular pH (pH(o)) stron...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3481314/ https://ncbi.nlm.nih.gov/pubmed/22948150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.398164 |
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