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Modeling, Substrate Docking, and Mutational Analysis Identify Residues Essential for the Function and Specificity of a Eukaryotic Purine-Cytosine NCS1 Transporter

The recent elucidation of crystal structures of a bacterial member of the NCS1 family, the Mhp1 benzyl-hydantoin permease from Microbacterium liquefaciens, allowed us to construct and validate a three-dimensional model of the Aspergillus nidulans purine-cytosine/H(+) FcyB symporter. The model consis...

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Bibliografske podrobnosti
Main Authors: Krypotou, Emilia, Kosti, Vasiliki, Amillis, Sotiris, Myrianthopoulos, Vassilios, Mikros, Emmanuel, Diallinas, George
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481282/
https://ncbi.nlm.nih.gov/pubmed/22969088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.400382
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