Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation

The ubiquitin–proteasome system targets selected proteins for degradation by the 26S proteasome. Rpn12 is an essential component of the 19S regulatory particle and plays a role in recruiting the extrinsic ubiquitin receptor Rpn10. In the present paper we report the crystal structure of Rpn12, a prot...

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Detalhes bibliográficos
Main Authors: Boehringer, Jonas, Riedinger, Christiane, Paraskevopoulos, Konstantinos, Johnson, Eachan O. D., Lowe, Edward D., Khoudian, Christina, Smith, Dominique, Noble, Martin E. M., Gordon, Colin, Endicott, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481250/
https://ncbi.nlm.nih.gov/pubmed/22906049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120542
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