Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways

The naturally occurring polyamine spermidine (Spd) has recently been shown to promote longevity across species in an autophagy-dependent manner. Here, we demonstrate that Spd improves both survival and locomotor activity of the fruit fly Drosophila melanogaster upon exposure to the superoxide genera...

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Hlavní autoři: Minois, N, Carmona-Gutierrez, D, Bauer, M A, Rockenfeller, P, Eisenberg, T, Brandhorst, S, Sigrist, S J, Kroemer, G, Madeo, F
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481127/
https://ncbi.nlm.nih.gov/pubmed/23059820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.139
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