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Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence

The μ-opioid receptor mediates rewarding effects of alcohol and illicit drugs. We hypothesized that altered DNA methylation in the μ-opioid receptor gene (OPRM1) might influence the vulnerability to alcohol dependence (AD). Genomic DNA was extracted from the peripheral blood of 125 European American...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Huiping, Herman, Aryeh I, Kranzler, Henry R, Anton, Raymond F, Simen, Arthur A, Gelernter, Joel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481015/
https://ncbi.nlm.nih.gov/pubmed/22914673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jhg.2012.98
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