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Structure and Ligand Based Drug Design Strategies in the Development of Novel 5-LOX Inhibitors
Lipoxygenases (LOXs) are non-heme iron containing dioxygenases involved in the oxygenation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA). Depending on the position of insertion of oxygen, LOXs are classified into 5-, 8-, 9-, 12- and 15-LOX. Among these, 5-LOX is the most predo...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Bentham Science Publishers
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3480706/ https://ncbi.nlm.nih.gov/pubmed/22680930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/092986712801661112 |
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