Inflammation and Gli2 Suppress Gastrin Gene Expression in a Murine Model of Antral Hyperplasia

Chronic inflammation in the stomach can lead to gastric cancer. We previously reported that gastrin-deficient (Gast(−/−)) mice develop bacterial overgrowth, inflammatory infiltrate, increased Il-1β expression, antral hyperplasia and eventually antral tumors. Since Hedgehog (Hh) signaling is active i...

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Bibliografiska uppgifter
Huvudupphovsmän: Saqui-Salces, Milena, Covés-Datson, Evelyn, Veniaminova, Natalia A., Waghray, Meghna, Syu, Li-Jyun, Dlugosz, Andrzej A., Merchant, Juanita L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480483/
https://ncbi.nlm.nih.gov/pubmed/23110168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048039
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