Activity-Based Protein Profiling Reveals Mitochondrial Oxidative Enzyme Impairment and Restoration in Diet-Induced Obese Mice

High-fat diet (HFD) induced obesity and concomitant development of insulin resistance (IR) and type 2 diabetes mellitus have been linked to mitochondrial dysfunction. However, it is not clear whether mitochondrial dysfunction is a direct effect of a HFD, or if mitochondrial function is reduced with...

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Main Authors: Sadler, Natalie C., Angel, Thomas E., Lewis, Michael P., Pederson, LeeAnna M., Chauvigné-Hines, Lacie M., Wiedner, Susan D., Zink, Erika M., Smith, Richard D., Wright, Aaron T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480472/
https://ncbi.nlm.nih.gov/pubmed/23110155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047996
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