Upregulation of the Tim-3/Galectin-9 Pathway of T Cell Exhaustion in Chronic Hepatitis B Virus Infection

The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation. We investigated whether galectin-9/Tim-3 interactions contribute to the deletion and exhaustion of the antiviral T cell response in chronic hepatit...

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Bibliografiske detaljer
Main Authors: Nebbia, Gaia, Peppa, Dimitra, Schurich, Anna, Khanna, Pooja, Singh, Harsimran D., Cheng, Yang, Rosenberg, William, Dusheiko, Geoffrey, Gilson, Richard, ChinAleong, Joanne, Kennedy, Patrick, Maini, Mala K.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480425/
https://ncbi.nlm.nih.gov/pubmed/23112829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047648
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