MeCP2 Dependent Heterochromatin Reorganization during Neural Differentiation of a Novel Mecp2-Deficient Embryonic Stem Cell Reporter Line

The X-linked Mecp2 is a known interpreter of epigenetic information and mutated in Rett syndrome, a complex neurological disease. MeCP2 recruits HDAC complexes to chromatin thereby modulating gene expression and, importantly regulates higher order heterochromatin structure. To address the effects of...

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Detalhes bibliográficos
Main Authors: Bertulat, Bianca, De Bonis, Maria Luigia, Della Ragione, Floriana, Lehmkuhl, Anne, Milden, Manuela, Storm, Christian, Jost, K. Laurence, Scala, Simona, Hendrich, Brian, D’Esposito, Maurizio, Cardoso, M. Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480415/
https://ncbi.nlm.nih.gov/pubmed/23112857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047848
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