Induction of antigen-specific tolerance by oral administration of Lactococcus lactis delivered immunodominant DQ8-restricted Gliadin peptide in sensitized NOD AB° DQ8 transgenic mice

Active delivery of recombinant autoantigens or allergens at the intestinal mucosa by genetically modified Lactococcus lactis (LL) provides a novel therapeutic approach for the induction of tolerance. Celiac disease is associated with either HLA-DQ2 or HLA-DQ8 restricted responses to specific antigen...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Huibregtse, Inge L., Marietta, Eric V., Rashtak, Shadi, Koning, Frits, Rottiers, Pieter, David, Chella S., van Deventer, Sander J.H., Murray, Joseph A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2009
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480315/
https://ncbi.nlm.nih.gov/pubmed/19635921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0802891
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