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Potential Role of Kringle-Integrin Interaction in Plasmin and uPA Actions (A Hypothesis)
We previously showed that the kringle domains of plasmin and angiostatin, the N-terminal four kringles (K1–4) of plasminogen, directly bind to integrins. Angiostatin blocks tumor-mediated angiogenesis and has great therapeutic potential. Angiostatin binding to integrins may be related to the antiinf...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Hindawi Publishing Corporation
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3480031/ https://ncbi.nlm.nih.gov/pubmed/23125522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/136302 |
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