Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells

An attractive strategy to overcome multidrug resistance in cancer chemotherapy is to suppress P-glycoprotein (P-gp), which is a pump overproduced in cancer cells to remove cytotoxic drugs from cells. In the present study, a Ca(2+)-permeable channel TRPC5 was found to be overproduced together with P-...

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Autors principals: Ma, Xin, Cai, Yanfei, He, Dongxu, Zou, Chang, Zhang, Peng, Lo, Chun Yin, Xu, Zhenyu, Chan, Franky L., Yu, Shan, Chen, Yun, Zhu, Ruiyu, Lei, Jianyong, Jin, Jian, Yao, Xiaoqiang
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479621/
https://ncbi.nlm.nih.gov/pubmed/22988121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202989109
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