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Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells
An attractive strategy to overcome multidrug resistance in cancer chemotherapy is to suppress P-glycoprotein (P-gp), which is a pump overproduced in cancer cells to remove cytotoxic drugs from cells. In the present study, a Ca(2+)-permeable channel TRPC5 was found to be overproduced together with P-...
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| Main Authors: | , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3479621/ https://ncbi.nlm.nih.gov/pubmed/22988121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202989109 |
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