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Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis

Lymphangiogenesis plays an important role in promoting cancer metastasis to sentinel lymph nodes and beyond and also promotes organ transplant rejection. We used human lymphatic endothelial cells to establish a reliable three-dimensional lymphangiogenic sprouting assay with automated image acquisiti...

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Autori principali: Schulz, Martin Michael Peter, Reisen, Felix, Zgraggen, Silvana, Fischer, Stephanie, Yuen, Don, Kang, Gyeong Jin, Chen, Lu, Schneider, Gisbert, Detmar, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479568/
https://ncbi.nlm.nih.gov/pubmed/22949700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206036109
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