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Structural basis for TetM-mediated tetracycline resistance

Ribosome protection proteins (RPPs) confer tetracycline resistance by binding to the ribosome and chasing the drug from its binding site. The current model for the mechanism of action of RPPs proposes that drug release is indirect and achieved via conformational changes within the drug-binding site...

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Detalhes bibliográficos
Main Authors: Dönhöfer, Alexandra, Franckenberg, Sibylle, Wickles, Stephan, Berninghausen, Otto, Beckmann, Roland, Wilson, Daniel N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479509/
https://ncbi.nlm.nih.gov/pubmed/23027944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208037109
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