Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B-Cell Lymphoma

Molecular signatures have identified several subsets of Diffuse Large B-Cell Lymphoma (DLBCL) and rational targets within the B-cell receptor (BCR) signaling axis. The OxPhos-DLBCL subset, which harbors the signature of genes involved in mitochondrial metabolism, is insensitive to inhibition of BCR...

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Bibliographic Details
Main Authors:	Caro, Pilar, Kishan, Amar U., Norberg, Erik, Stanley, Illana, Chapuy, Bjoern, Ficarro, Scott B., Polak, Klaudia, Tondera, Daniel, Gounarides, John, Yin, Hong, Zhou, Feng, Green, Michael R., Chen, Linfeng, Monti, Stefano, Marto, Jarrod A., Shipp, Margaret A., Danial, Nika N.
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3479446/ https://ncbi.nlm.nih.gov/pubmed/23079663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.08.014
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Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B-Cell Lymphoma

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