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Genetic interactions of hypomorphic mutations in the m(7)G cap-binding pocket of yeast nuclear cap binding complex: An essential role for Cbc2 in meiosis via splicing of MER3 pre-mRNA

Nuclear cap binding protein complex (CBC) is a heterodimer of a small subunit (Cbc2 in yeast) that binds the m(7)G cap and a large subunit (Sto1 in yeast) that interacts with karyopherins. In order to probe the role of cap recognition in yeast CBC function, we introduced alanine mutations (Y24A, F91...

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Autors principals: Qiu, Zhicheng R., Chico, Lidia, Chang, Jonathan, Shuman, Stewart, Schwer, Beate
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479390/
https://ncbi.nlm.nih.gov/pubmed/23002122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.033746.112
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