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The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes

The protein arginine methyltransferase 6 (PRMT6) is a coregulator of gene expression and executes its repressing as well as activating function by asymmetric dimethylation of histone H3 at R2 (H3 R2me2a). Given that elevated expression levels of PRMT6 have been reported in various cancer types, we e...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Stein, Claudia, Riedl, Stefanie, Rüthnick, Diana, Nötzold, René Reiner, Bauer, Uta-Maria
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479209/
https://ncbi.nlm.nih.gov/pubmed/22904088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks767
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