Alteration of Cellular Behavior and Response to PI3K Pathway Inhibition by Culture in 3D Collagen Gels

Most investigations into cancer cell drug response are performed with cells cultured on flat (2D) tissue culture plastic. Emerging research has shown that the presence of a three-dimensional (3D) extracellular matrix (ECM) is critical for normal cell behavior including migration, adhesion, signaling...

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Main Authors: Fallica, Brian, Maffei, Joseph S., Villa, Shaun, Makin, Guy, Zaman, Muhammad
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479126/
https://ncbi.nlm.nih.gov/pubmed/23110163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048024
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