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Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen
B cell tolerance to self-antigen is critical to preventing antibody-mediated autoimmunity. Previous work using B cell antigen receptor transgenic animals suggested that self-antigen–specific B cells are either deleted from the repertoire, enter a state of diminished function termed anergy, or are ig...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3478923/ https://ncbi.nlm.nih.gov/pubmed/23071255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112272 |
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