Antineoplastic Effects of Decitabine, an Inhibitor of DNA Promoter Methylation, in Adrenocortical Carcinoma Cells

HYPOTHESES: Decitabine recovers expression of silenced genes on chromosome 11q13 and has antineoplastic effects in adrenocortical carcinoma (ACC) cells. DESIGN: NCI-H295R cells were treated with decitabine (0.1–1.0μM) over 5 days. Cells were evaluated at 24-hour intervals for the effects of decitabi...

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Main Authors: Suh, Insoo, Weng, Julie, Fernandez-Ranvier, Gustavo, Shen, Wen T., Duh, Quan-Yang, Clark, Orlo H., Kebebew, Electron
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478887/
https://ncbi.nlm.nih.gov/pubmed/20231622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/archsurg.2009.292
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