Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs

MUC5AC, a major gel-forming mucin expressed in the lungs, is secreted at increased rates in response to infectious agents, implying that mucins exert a protective role against inhaled pathogens. However, epidemiological and pathological studies suggest that excessive mucin secretion causes airways o...

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Bibliographic Details
Main Authors: Ehre, Camille, Worthington, Erin N., Liesman, Rachael M., Grubb, Barbara R., Barbier, Diane, O’Neal, Wanda K., Sallenave, Jean-Michel, Pickles, Raymond J., Boucher, Richard C.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478656/
https://ncbi.nlm.nih.gov/pubmed/23012413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206552109
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