EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore–microtubule interactions in mitosis

In eukaryotes, microtubules are essential for cellular plasticity and dynamics. Here we show that P300/CBP-associated factor (PCAF), a kinetochore-associated acetyltransferase, acts as a negative modulator of microtubule stability through acetylation of EB1, a protein that controls the plus ends of...

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Main Authors: Xia, Peng, Wang, Zhikai, Liu, Xing, Wu, Bing, Wang, Juncheng, Ward, Tarsha, Zhang, Liangyu, Ding, Xia, Gibbons, Gary, Shi, Yunyu, Yao, Xuebiao
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478649/
https://ncbi.nlm.nih.gov/pubmed/23001180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202639109
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