β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway

Proteinase-Activated rreceptor-2 (PAR(2)), a G-protein–coupled Receptor, activated by serine proteinases, is reported to have both protective and proinflammatory effects in the airway. Given these opposing actions, both inhibitors and activators of PAR(2) have been proposed for treating asthma. PAR(...

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Detaylı Bibliyografya
Asıl Yazarlar: Nichols, Heddie L., Saffeddine, Mahmoud, Theriot, Barbara S., Hegde, Akhil, Polley, Daniel, El-Mays, Tamer, Vliagoftis, Harissios, Hollenberg, Morley D., Wilson, Emma H., Walker, Julia K. L., DeFea, Kathryn A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2012
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478622/
https://ncbi.nlm.nih.gov/pubmed/23012429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208881109
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