β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway

Proteinase-Activated rreceptor-2 (PAR(2)), a G-protein–coupled Receptor, activated by serine proteinases, is reported to have both protective and proinflammatory effects in the airway. Given these opposing actions, both inhibitors and activators of PAR(2) have been proposed for treating asthma. PAR(...

Full description

Saved in:
Bibliographic Details
Main Authors: Nichols, Heddie L., Saffeddine, Mahmoud, Theriot, Barbara S., Hegde, Akhil, Polley, Daniel, El-Mays, Tamer, Vliagoftis, Harissios, Hollenberg, Morley D., Wilson, Emma H., Walker, Julia K. L., DeFea, Kathryn A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478622/
https://ncbi.nlm.nih.gov/pubmed/23012429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208881109
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items