β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway

Proteinase-Activated rreceptor-2 (PAR(2)), a G-protein–coupled Receptor, activated by serine proteinases, is reported to have both protective and proinflammatory effects in the airway. Given these opposing actions, both inhibitors and activators of PAR(2) have been proposed for treating asthma. PAR(...

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Autors principals: Nichols, Heddie L., Saffeddine, Mahmoud, Theriot, Barbara S., Hegde, Akhil, Polley, Daniel, El-Mays, Tamer, Vliagoftis, Harissios, Hollenberg, Morley D., Wilson, Emma H., Walker, Julia K. L., DeFea, Kathryn A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478622/
https://ncbi.nlm.nih.gov/pubmed/23012429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208881109
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